Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum.

ABSTRACT: Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate the functions of longevity-associated variants. Using a cohort of centenarians with maintained cognitive health (N = 343), a population-matched cohort of older adults from 5 cohorts (N = 2905), and summary statistics data from genome-wide association studies on parental longevity, we constructed a PRS including 330 variants that significantly discriminated between centenarians and older adults. This PRS was also associated with longer survival in an independent sample of younger individuals (p = .02), leading up to a 4-year difference in survi

SUBMITTER: Tesi N 

PROVIDER: S-EPMC8087277 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature