Chronic hypoparathyroidism and treatment with teriparatide.

ABSTRACT:

Purpose

Chronic hypoparathyroidism is usually treated with calcium and active vitamin D metabolites or analogs, despite the fact that their chronic use can lead to long-term complications. The use of hormone replacement therapy with PTH peptides [teriparatide and rhPTH (1-84)] has therefore been proposed. The main purpose of this study was to investigate the efficacy of teriparatide dose at 20 µg once or twice daily, in order to maintain normocalcemia reducing standard treatment, in adult patients with chronic hypoparathyroidism not well controlled with conventional treatment.

Methods

The study was a Phase III, open-label, non-comparative, clinical investigation (study period: 3 months), at a tertiary care clinical research center. Thirty patients with chronic hypoparathyroi

SUBMITTER: Marcucci G 

PROVIDER: S-EPMC8087564 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature