Clinical features of ProMisE groups identify different phenotypes of patients with endometrial cancer.

ABSTRACT:

Background

The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) groups has identified four molecular prognostic groups of endometrial cancer (EC): POLE-mutated (POLE-mt), mismatch repair-deficient (MMR-d), p53-abnormal (p53-abn), p53-wild-type (p53-wt). These groups might have different pathogenesis and risk factors, and might occur in different phenotypes of patients. However, these data are still lacking.

Objective

To provide a clinical characterization of the ProMisE groups of EC.

Methods

A systematic review and meta-analysis was performed by searching seven electronic databases from their inception to December 2020, for all studies reporting clinical characteristics of EC patients in each ProMisE group. Pooled means of age and BMI and pooled pr

SUBMITTER: Raffone A 

PROVIDER: S-EPMC8087601 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature