Longitudinal associations between exposure to anesthesia and neurocognitive functioning in pediatric medulloblastoma.

ABSTRACT:

Aim

To examine whether anesthesia exposure is associated with neurocognitive decline in pediatric medulloblastoma.

Methods

Patients were treated at St. Jude Children's Research Hospital and completed ≥2 protocol-directed neurocognitive assessments (n = 107) as part of a multisite clinical trial for pediatric medulloblastoma (NCT00085202). Patients received risk-adapted craniospinal photon irradiation, followed by four cycles of high-dose chemotherapy and stem cell rescue. Neurocognitive testing was completed at study baseline (after surgery and <2 weeks of starting radiation therapy) and annually for 5 years. Data on anesthesia exposure during treatment was abstracted from medical records.

Results

Patients were 10.2 years at diagnosis on average (SD = 4.5; 37% female,

SUBMITTER: Partanen M 

PROVIDER: S-EPMC8087638 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature