Molecular pathology as a diagnostic aid in difficult-to-classify melanocytic tumours with spitzoid morphology.

ABSTRACT: Accurate classification of melanocytic proliferations has important implications for prognostic prediction, treatment and follow-up. Although most melanocytic proliferations can be accurately classified using clinical and pathological criteria, classification (specifically distinction between nevus and melanoma) can be challenging in a subset of cases, including those with spitzoid morphology. Genetic studies have shown that mutation profiles differ between primary melanoma subtypes and Spitz nevi. These differences may aid in distinguishing benign from malignant in some melanocytic tumours. Here, we present a selection of melanocytic proliferations with equivocal histopathological criteria, wherein genetic analysis was requested to help guide classification. In two of four cases, the gene

SUBMITTER: Zaremba A 

PROVIDER: S-EPMC8087654 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature