Unraveling the molecular crosstalk between Atherosclerosis and COVID-19 comorbidity.

ABSTRACT:

Background

Corona virus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has created ruckus throughout the world. Growing epidemiological studies have depicted atherosclerosis as a comorbid factor of COVID-19. Though both these diseases are triggered via inflammatory rage that leads to injury of healthy tissues, the molecular linkage between them and their co-influence in causing fatality is not yet understood.

Methods

We have retrieved the data of differentially expressed genes (DEGs) for both atherosclerosis and COVID-19 from publicly available microarray and RNA-Seq datasets. We then reconstructed the protein-protein interaction networks (PPIN) for these diseases from protein-protein interaction data of corresponding DEGs. Us

SUBMITTER: Das D 

PROVIDER: S-EPMC8088080 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature