IsoResolve: predicting splice isoform functions by integrating gene and isoform-level features with domain adaptation.

ABSTRACT:

Motivation

High resolution annotation of gene functions is a central goal in functional genomics. A single gene may produce multiple isoforms with different functions through alternative splicing. Conventional approaches, however, consider a gene as a single entity without differentiating these functionally different isoforms. Towards understanding gene functions at higher resolution, recent efforts have focused on predicting the functions of isoforms. However, the performance of existing methods is far from satisfactory mainly because of the lack of isoform-level functional annotation.

Results

We present IsoResolve, a novel approach for isoform function prediction, which leverages the information from gene function prediction models with domain adaptation (DA). IsoResolve t

SUBMITTER: Li HD 

PROVIDER: S-EPMC8088322 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature