Precision Medicine and cardiac channelopathies: when dreams meet reality.

ABSTRACT: Precision Medicine (PM) is an innovative approach that, by relying on large populations' datasets, patients' genetics and characteristics, and advanced technologies, aims at improving risk stratification and at identifying patient-specific management through targeted diagnostic and therapeutic strategies. Cardiac channelopathies are being progressively involved in the evolution brought by PM and some of them are benefiting from these novel approaches, especially the long QT syndrome. Here, we have explored the main layers that should be considered when developing a PM approach for cardiac channelopathies, with a focus on modern in vitro strategies based on patient-specific human-induced pluripotent stem cells and on in silico models. PM is where scientists and clinicians must meet and inte

SUBMITTER: Gnecchi M 

PROVIDER: S-EPMC8088342 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature