Mesolimbic opioid-dopamine interaction is disrupted in obesity but recovered by weight loss following bariatric surgery.

ABSTRACT: Obesity is a growing burden to health and the economy worldwide. Obesity is associated with central µ-opioid receptor (MOR) downregulation and disruption of the interaction between MOR and dopamine D₂ receptor (D₂R) system in the ventral striatum. Weight loss recovers MOR function, but it remains unknown whether it also recovers aberrant opioid-dopamine interaction. Here we addressed this issue by studying 20 healthy non-obese and 25 morbidly obese women (mean BMI 41) eligible for bariatric surgery. Brain MOR and D₂R availability were measured using positron emission tomography (PET) with [¹¹C]carfentanil and [¹¹C]raclopride, respectively. Either Roux-en-Y gastric bypass or sleeve gastrectomy was performed on obese subjects according t

SUBMITTER: Karlsson HK 

PROVIDER: S-EPMC8088437 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature