Taxane-induced Attenuation of the CXCR2/BCL-2 Axis Sensitizes Prostate Cancer to Platinum-based Treatment.

ABSTRACT:

Background

Taxanes are the most active chemotherapy agents in metastatic castration-resistant prostate cancer (mCRPC) patients; yet, resistance occurs almost invariably, representing an important clinical challenge. Taxane-platinum combinations have shown clinical benefit in a subset of patients, but the mechanistic basis and biomarkers remain elusive.

Objective

To identify mechanisms and response indicators for the antitumor efficacy of taxane-platinum combinations in mCRPC.

Design, setting, and participants

Transcriptomic data from a publicly available mCRPC dataset of taxane-exposed and taxane-naïve patients were analyzed to identify response indicators and emerging vulnerabilities. Functional and preclinical validation was performed in taxane-resistant mCRPC cell

SUBMITTER: Ruiz de Porras V 

PROVIDER: S-EPMC8088452 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature