Carbon Source-Dependent Reprogramming of Anaerobic Metabolism in Staphylococcus aureus.

ABSTRACT: To be a successful pathogen, Staphylococcus aureus has to adapt its metabolism to the typically oxygen- and glucose-limited environment of the host. Under fermenting conditions and in the presence of glucose, S. aureus uses glycolysis to generate ATP via substrate-level phosphorylation and mainly lactic acid fermentation to maintain the redox balance by reoxidation of NADH equivalents. However, it is less clear how S. aureus proceeds under anoxic conditions and glucose limitation, likely representing the bona fide situation in the host. Using a combination of proteomic, transcriptional, and metabolomic analyses, we show that in the absence of an abundant glycolysis substrate, the available carbon source pyruvate is converted to acetyl coenzyme A (AcCoA) in a pyruvate f

SUBMITTER: Troitzsch A 

PROVIDER: S-EPMC8088510 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature