Sex and APOE genotype differences related to statin use in the aging population.

ABSTRACT:

Background

Significant evidence suggests that the cholesterol-lowering statins can affect cognitive function and reduce the risk for Alzheimer's disease (AD) and dementia. These potential effects may be constrained by specific combinations of an individual's sex and apolipoprotein E (APOE) genotype.

Methods

Here we examine data from 252,327 UK Biobank participants, aged 55 or over, and compare the effects of statin use in males and females. We assessed difference in statin treatments taking a matched cohort approach, and identified key stratifiers using regression models and conditional inference trees. Using statistical modeling, we further evaluated the effect of statins on survival, cognitive decline over time, and on AD prevalence.

Results

We identified tha

SUBMITTER: Dagliati A 

PROVIDER: S-EPMC8088592 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature