Serum proteomic profiling in patients with advanced Schistosoma japonicum-induced hepatic fibrosis.

ABSTRACT:

Background

Schistosoma japonicum is a parasitic flatworm that is the aetiological agent of human schistosomiasis, an important cause of hepatic fibrosis. Schistosomiasis-induced hepatic fibrosis is a consequence of the highly fibrogenic nature of egg-induced granulomatous lesions, which are the main pathogenic features of schistosomiasis. Although global awareness of the association between schistosomiasis-induced hepatic fibrosis and S. japonicum infection is increasing, little is known about the molecular differences associated with rapid progression to schistosomiasis in cirrhotic patients.

Methods

We systematically used data-independent acquisition (DIA)-based liquid chromatography-mass spectrometry to identify differentially expressed proteins in serum samples from pati

SUBMITTER: Huang J 

PROVIDER: S-EPMC8088642 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature