LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis.

ABSTRACT:

Background

Leucine rich repeat containing 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), belongs to the superfamily of LRR proteins and serves as a receptor for netrin-G2. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation. Mutations in LRRC4 occur in Autism Spectrum Disorder (ASD) and intellectual disability. Multiple sclerosis (MS) is a chronic neuroinflammatory disease with spinal cords demyelination and neurodegeneration. Here, we sought to investigate whether LRRC4 is involved in spinal cords neuron-associated diseases.

Methods

LRRC4 was detected in the CNS of experimental autoimmune encephalomyelitis (EAE) mice by the use of real-time PCR and western blotting. LRRC4^-/- mice were created and immunized with myelin oligo

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8088686 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature