Chimeric antigen receptor natural killer (CAR-NK) cell design and engineering for cancer therapy.

ABSTRACT: Due to their efficient recognition and lysis of malignant cells, natural killer (NK) cells are considered as specialized immune cells that can be genetically modified to obtain capable effector cells for adoptive cellular treatment of cancer patients. However, biological and technical hurdles related to gene delivery into NK cells have dramatically restrained progress. Recent technological advancements, including improved cell expansion techniques, chimeric antigen receptors (CAR), CRISPR/Cas9 gene editing and enhanced viral transduction and electroporation, have endowed comprehensive generation and characterization of genetically modified NK cells. These promising developments assist scientists and physicians to design better applications of NK cells in clinical therapy. Notably, redirect

SUBMITTER: Gong Y 

PROVIDER: S-EPMC8088725 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature