The value of genomic relationship matrices to estimate levels of inbreeding.

ABSTRACT:

Background

Genomic relationship matrices are used to obtain genomic inbreeding coefficients. However, there are several methodologies to compute these matrices and there is still an unresolved debate on which one provides the best estimate of inbreeding. In this study, we investigated measures of inbreeding obtained from five genomic matrices, including the Nejati-Javaremi allelic relationship matrix (F_NEJ), the Li and Horvitz matrix based on excess of homozygosity (F_L&H), and the VanRaden (methods 1, F_VR1, and 2, F_VR2) and Yang (F_YAN) genomic relationship matrices. We derived expectations for each inbreeding coefficient, assuming a single locus model, and used these expectations to explain the patterns of the coefficients that

SUBMITTER: Villanueva B 

PROVIDER: S-EPMC8088726 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature