Blockade of RGMb inhibits allergen-induced airways disease.

ABSTRACT:

Background

Allergic asthma causes morbidity in many subjects, and novel precision-directed treatments would be valuable.

Objective

We sought to examine the role of a novel innate molecule, repulsive guidance molecule b (RGMb), in murine models of allergic asthma.

Methods

In models of allergic asthma using ovalbumin or cockroach allergen, mice were treated with anti-RGMb or control mAb and examined for airway inflammation and airway hyperreactivity (AHR), a cardinal feature of asthma. The mechanisms by which RGMb causes airways disease were also examined.

Results

We found that blockade of RGMb by treatment with anti-RGMb mAb effectively blocked the development of airway inflammation and AHR. Importantly, blockade of RGMb completely blocked the development of air

SUBMITTER: Yu S 

PROVIDER: S-EPMC8088837 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature