Torsade de pointes associated with chloroquine, hydroxychloroquine, and azithromycin: a retrospective analysis of individual case safety reports from VigiBase.

ABSTRACT:

Purpose

To analyze the cases of torsade de pointes (TdP) and related symptoms reported in association with chloroquine (CQ), hydroxychloroquine (HCQ), and azithromycin (AZT) to the World Health Organization (WHO) global database of individual case safety reports (ICSRs) for drug monitoring (VigiBase) using qualitative and quantitative pharmacovigilance approaches.

Methods

The main characteristics of the ICSRs reporting TdP with CQ, HCQ, and AZT have been summarized. Co-reported drugs with risk to cause QT prolongation have been described. Reporting odds ratios (RORs) as a measure of disproportionality for reported TdP and individual drugs have been calculated.

Results

One hundred seventy ICSRs reporting TdP in association with the drugs of interest were identified (CQ

SUBMITTER: Saint-Gerons DM 

PROVIDER: S-EPMC8089128 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature