In-Silico Analysis of Key Regulatory Pathways and Hub Genes From Peripheral Blood in Type 2 Diabetes Mellitus

ABSTRACT: Abstract AbstractBackground: Type II diabetes mellitus (T2DM), characterized by fasting hyperglycemia and impaired insulin secretion and action, is a global health burden. Despite the advances in this field, the mechanism underlying T2DM is far from clear. Objective: The present study sheds light upon a systematic evaluation of the genes, pathways, and interaction networks underlying T2DM with the aid of bioinformatics. Methods: Two Gene Expression Omnibus microarray datasets: GSE148961 and GSE26168 were selected for this study. The common differentially expressed genes (DEG) were sorted by the cutoff |logFC|≥1.0 for the first dataset and |logFC|≥0.263 for the second. Gene Ontology (GO), functional enrichment, and protein-protein interaction (PPI) network were analyzed in Search Tool for t

SUBMITTER: Purohit P 

PROVIDER: S-EPMC8090555 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature