Eight-week antidepressant treatment reduces functional connectivity in first-episode drug-naive patients with major depressive disorder.

ABSTRACT: Previous neuroimaging studies have revealed abnormal functional connectivity of brain networks in patients with major depressive disorder (MDD), but findings have been inconsistent. A recent big-data study found abnormal intrinsic functional connectivity within the default mode network in patients with recurrent MDD but not in first-episode drug-naïve patients with MDD. This study also provided evidence for reduced default mode network functional connectivity in medicated MDD patients, raising the question of whether previously observed abnormalities may be attributable to antidepressant effects. The present study (ClinicalTrials.gov identifier: NCT03294525) aimed to disentangle the effects of antidepressant treatment from the pathophysiology of MDD and test the medication normalization hy

SUBMITTER: Li L 

PROVIDER: S-EPMC8090770 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature