Clinical Features of Breast Cancer in South Korean Patients with Germline TP53 Gene Mutations.

ABSTRACT:

Purpose

Li-Fraumeni syndrome (LFS) is a rare autosomal cancer syndrome caused by a germline mutation in the TP53 gene. Breast cancer in LFS patients is of various subtypes; however, limited data are available on the clinicopathological features of these subtypes and their appropriate treatments. This study aimed to review the clinical features and treatments for breast cancer in South Korean patients with germline TP53 mutations.

Methods

Data on the clinicopathological features and treatment of all breast cancer patients with LFS were collected retrospectively from the available database of 4 tertiary hospitals in the Republic of Korea.

Results

Twenty-one breast cancer cases in 12 unrelated women with confirmed germline TP53 mutations were include

SUBMITTER: Alyami H 

PROVIDER: S-EPMC8090805 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature