Characterization of Aspergillus fumigatus cross-resistance between clinical and DMI azole drugs.

ABSTRACT: Drug resistance poses a serious threat to human health and agricultural production. Azole drugs are the largest group of 14-α sterol demethylation inhibitor fungicides that are used both in agriculture and in clinical practice. As plant pathogenic molds share their natural environment with fungi that cause opportunistic infections in humans, both are exposed to a strong and persistent pressure of demethylase inhibitor (DMI) fungicides, including imidazole and triazole drugs. As a result, a loss of efficacy has occurred for this drug class in several species. In the clinical setting, Aspergillus fumigatus azole resistance is a growing public health problem and finding the source of this resistance has gained much attention. It is urgent to determine if there is a direct link between

SUBMITTER: Garcia-Rubio R 

PROVIDER: S-EPMC8090891 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature