The DUG Pathway Governs Degradation of Intracellular Glutathione in Aspergillus nidulans.

ABSTRACT: Glutathione (GSH) is an abundant tripeptide that plays a crucial role in shielding cellular macromolecules from various reactive oxygen and nitrogen species in fungi. Understanding GSH metabolism is of vital importance for deciphering redox regulation in these microorganisms. In the present study, to better understand the GSH metabolism in filamentous fungi, we investigated functions of the dugB and dugC genes in the model fungus Aspergillus nidulans These genes are orthologues of dug2 and dug3, which are involved in cytosolic GSH degradation in Saccharomyces cerevisiae The deletion of dugB, dugC, or both resulted in a moderate increase in the GSH content in mycelia grown on glucose, reduced conidium production, and disturbed sexual d

SUBMITTER: Gila BC 

PROVIDER: S-EPMC8091023 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature