ISTH guidelines for treatment of thrombotic thrombocytopenic purpura.

ABSTRACT:

Background

Despite advances in treatment options for thrombotic thrombocytopenic purpura (TTP), there are still limited high quality data to inform clinicians regarding its appropriate treatment.

Methods

In June 2018, the ISTH formed a multidisciplinary guideline panel to issue recommendations about treatment of TTP. The panel discussed 12 treatment questions related to immune-mediated TTP (iTTP) and hereditary or congenital TTP (cTTP). The panel used the Grading of Recommendations Assessment, Development, and Evaluation approach, including evidence-to-decision frameworks, to appraise evidence and formulate recommendations.

Results

The panel agreed on 11 recommendations based on evidence ranging from very low to moderate certainty. For first acute episode and relapses

SUBMITTER: Zheng XL 

PROVIDER: S-EPMC8091490 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature