Sex differences associated with adverse drug reactions resulting in hospital admissions.

ABSTRACT:

Background

Adverse drug events, including adverse drug reactions (ADRs), are responsible for approximately 5% of unplanned hospital admissions: a major health concern. Women are 1.5-1.7 times more likely to develop ADRs. The main objective was to identify sex differences in the types and number of ADRs leading to hospital admission.

Methods

ADR-related hospital admissions between 2005 and 2017 were identified from the PHARMO Database Network using hospital discharge diagnoses. Patients aged ≥ 16 years with a drug possibly responsible for the ADR and dispensed within 3 months before admission were included. Age-adjusted odds ratios (OR) with 95% CIs for drug-ADR combinations for women versus men were calculated.

Results

A total of 18,469 ADR-related hospital admissions

SUBMITTER: Hendriksen LC 

PROVIDER: S-EPMC8091530 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature