Anna Karenina and the subgingival microbiome associated with periodontitis.

ABSTRACT:

Background

Although localized aggressive periodontitis (LAP), generalized aggressive periodontitis (GAP), and chronic periodontitis (CP) are microbially driven diseases, our inability to separate disease-specific associations from those common to all three forms of periodontitis has hampered biomarker discovery. Therefore, we aimed to map the genomic content of, and the biological pathways encoded by, the microbiomes associated with these clinical phenotypes. We also estimated the extent to which these biomes are governed by the Anna Karenina principle (AKP), which states that eubiotic communities are similar between individuals while disease-associated communities are highly individualized.

Methods

We collected subgingival plaque from 25 periodontally healthy individuals an

SUBMITTER: Altabtbaei K 

PROVIDER: S-EPMC8091542 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature