Triclosan Tolerance Is Driven by a Conserved Mechanism in Diverse Pseudomonas Species.

ABSTRACT: Perturbation of natural microbial communities by antimicrobials, such as triclosan, can result in selection for antibiotic tolerance, which is of particular concern when pathogens are present. Members of the genus Pseudomonas are found in many natural microbial communities and frequently demonstrate increased abundance following triclosan exposure. The pathogen and well-studied model organism Pseudomonas aeruginosa exhibits high triclosan tolerance; however, it is unknown if all Pseudomonas species share this trait or if there are susceptible strains. We characterized the triclosan tolerance phenotypes of diverse Pseudomonas isolates obtained from triclosan-exposed built environments and identified both tolerant and sensitive strains. High tolerance is associate

SUBMITTER: McFarland AG 

PROVIDER: S-EPMC8091609 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature