B lymphocyte-induced maturation protein 1 controls T_H9 cell development, IL-9 production, and allergic inflammation.

ABSTRACT:

Background

The transcriptional repressor B lymphocyte-induced maturation protein 1 (Blimp-1) has a key role in terminal differentiation in various T-cell subtypes. However, whether Blimp-1 regulates T_H9 differentiation and its role in allergic inflammation are unknown.

Objective

We aimed to investigate the role of Blimp-1 in T_H9 differentiation and in the pathogenesis of allergic airway inflammation.

Methods

In vitro T_H9 differentiation, flow cytometry, ELISA, and real-time PCR were used to investigate the effects of Blimp-1 on T_H9 polarization. T cell-specific Blimp-1-deficient mice, a model of allergic airway inflammation, and T-cell adoptive transfer to recombination-activating gene 1 (Rag-1)^-/- mice were used

SUBMITTER: Benevides L 

PROVIDER: S-EPMC8091629 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature