Infant rhesus macaques as a non-human primate model of Bordetella pertussis infection.

ABSTRACT:

Background

The prevalent resurgence of pertussis has recently become a critical public health problem worldwide. To understand pertussis pathogenesis and the host response to both the pathogen and vaccines, a suitable pertussis animal model, particularly a non-human primate model, is necessary. Recently, a non-human primate pertussis model was successfully established with baboons. Rhesus macaques have been shown to be ideal animal models for several infectious diseases, but a model of infectious pertussis has not been established in these organisms. Studies on rhesus macaque models of pertussis were performed in the 1920s-1930s, but limited experimental details are available. Recent monkey pertussis models have not been successful because the typical clinical symptoms and transmis

SUBMITTER: Jiang W 

PROVIDER: S-EPMC8091708 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature