Molecular evolutionary analysis of human primary microcephaly genes.

ABSTRACT:

Background

There has been a rapid increase in the brain size relative to body size during mammalian evolutionary history. In particular, the enlarged and globular brain is the most distinctive anatomical feature of modern humans that set us apart from other extinct and extant primate species. Genetic basis of large brain size in modern humans has largely remained enigmatic. Genes associated with the pathological reduction of brain size (primary microcephaly-MCPH) have the characteristics and functions to be considered ideal candidates to unravel the genetic basis of evolutionary enlargement of human brain size. For instance, the brain size of microcephaly patients is similar to the brain size of Pan troglodyte and the very early hominids like the Sahelanthropus tchadensis and Austr

SUBMITTER: Pervaiz N 

PROVIDER: S-EPMC8091745 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature