Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL.

ABSTRACT: IDH1 and IDH2 mutations (IDH1/2^Mut) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent development of specific IDH1/2^Mut inhibitors. In T-cell acute lymphoblastic leukemia (T-ALL), their incidence and prognostic implications remain poorly reported. Our targeted next-generation sequencing approach allowed comprehensive assessment of genotype across the entire IDH1 and IDH2 locus in 1085 consecutive unselected and newly diagnosed patients with T-ALL and identified 4% of, virtually exclusive (47 of 49 patients), IDH1/2^Mut. Mutational patterns of IDH1/2^Mut in T-ALL present some specific features compared to AML. Whereas IDH2^R140Q</

SUBMITTER: Simonin M 

PROVIDER: S-EPMC8091755 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature