DNA methylation profiling for molecular classification of adult diffuse lower-grade gliomas.

ABSTRACT:

Background

DNA methylation profiling has facilitated and improved the classification of a wide variety of tumors of the central nervous system. In this study, we investigated the potential utility of DNA methylation profiling to achieve molecular diagnosis in adult primary diffuse lower-grade glioma (dLGG) according to WHO 2016 classification system. We also evaluated whether methylation profiling could provide improved molecular characterization and identify prognostic differences beyond the classical histological WHO grade together with IDH mutation status and 1p/19q codeletion status. All patients diagnosed with dLGG in the period 2007-2016 from the Västra Götaland region in Sweden were assessed for inclusion in the study.

Results

A total of 166 dLGG cases were subjected

SUBMITTER: Ferreyra Vega S 

PROVIDER: S-EPMC8091784 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature