Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4⁺ and CD8⁺ T effector memory cells and increase of T regulatory cells.

ABSTRACT: BK virus (BKV), a human polyomavirus that remains latent in renal epithelial cells, can be reactivated after hematopoietic stem cell transplantation (HSCT) leading to hemorrhagic cystitis. The incidence of BK viremia is higher after Umbilical cord blood transplantation (UCBT) than HSCT from adult donors. Data regarding the role of immune recovery after UCBT in BKV reactivation is lacking. We examined the correlation between the development of BK viremia and immune reconstitution in 27 adult recipients of UCBT. The incidence of BK viremia was 52% and developed most frequently within the first 8 weeks after the transplantation, but persisted in seven patients at 6 months, and three patients at 1-year post UCBT. Detection of BK viremia 1 year after transplant was negatively associated with th

SUBMITTER: Karantanos T 

PROVIDER: S-EPMC8091796 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature