Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC8091817 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Jin Yuxiao Y Chen Zhiyuan Z Dong Jiali J Wang Bin B Fan Saijun S Yang Xiaodong X Cui Ming M
FEBS open bio 20210501 5
Acquired and intrinsic radioresistance remains a major challenge during the treatment of patients with colorectal cancer (CRC). Aberrant cholesterol metabolism precipitates the development of multiple cancers. Here, we report that exogenous or endogenous cholesterol enhances the radioresistance of CRC cells. The addition of cholesterol protects CRC cells against irradiation both in vitro and in vivo. Sterol response element-binding protein 1/fatty acid synthase (SREBP1/FASN) signaling is rapidly ...[more]