Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring.

ABSTRACT: Parental health influences embryonic development and susceptibility to disease in the offspring. We investigated whether maternal voluntary running during gestation could protect the offspring from the adverse effects of maternal or paternal high-fat diet (HF) in mice. We performed transcriptomic and whole-genome DNA methylation analyses in female offspring skeletal muscle and targeted DNA methylation analysis of the peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α) promoter in both male and female adult offspring. Maternal HF resulted in impaired metabolic homeostasis in male offspring at 9 mo of age, whereas both male and female offspring were negatively impacted by paternal HF. Maternal exercise during gestation completely mitigated these metabolic impairments.

SUBMITTER: Laker RC 

PROVIDER: S-EPMC8091938 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature