Mechanisms of Nicotine Addiction.

ABSTRACT: Tobacco smoking results in more than five million deaths each year and accounts for ∼90% of all deaths from lung cancer.³ Nicotine, the major reinforcing component of tobacco smoke, acts in the brain through the neuronal nicotinic acetylcholine receptors (nAChRs). The nAChRs are allosterically regulated, ligand-gated ion channels consisting of five membrane-spanning subunits. Twelve mammalian α subunits (α2-α10) and three β subunits (β2-β4) have been cloned. The predominant nAChR subtypes in mammalian brain are those containing α4 and β2 subunits (denoted as α4β2* nAChRs). The α4β2* nAChRs mediate many behaviors related to nicotine addiction and are the primary targets for currently approved smoking cessation agents. Considering the large number of nAChR subunits in the brain, i

SUBMITTER: Picciotto MR 

PROVIDER: S-EPMC8091956 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature