SARS-CoV-2 seroprevalence trends in healthy blood donors during the COVID-19 outbreak in Milan.

ABSTRACT:

Background

The Milan metropolitan area in Northern Italy was among the most severely hit by the SARS-CoV-2 outbreak. The aim of this study was to examine the seroprevalence trends of SARS-CoV-2 in healthy asymptomatic adults, and the risk factors and laboratory correlates of positive tests.

Materials and methods

We conducted a cross-sectional study in a random sample of blood donors, who were asymptomatic at the time of evaluation, at the beginning of the first phase (February 24^th to April 8^th 2020; n=789). Presence of IgM/IgG antibodies against the SARS-CoV-2-Nucleocapsid protein was assessed by a lateral flow immunoassay.

Results

The test had a 100/98.3 sensitivity/specificity (n=32/120 positive/negative controls, respectively), and the IgG te

SUBMITTER: Valenti L 

PROVIDER: S-EPMC8092034 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature