Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 ^c259T Cells in Synovial Sarcoma.

ABSTRACT: We evaluated the safety and activity of autologous T cells expressing NY-ESO-1^c259, an affinity-enhanced T-cell receptor (TCR) recognizing an HLA-A2-restricted NY-ESO-1/LAGE1a-derived peptide, in patients with metastatic synovial sarcoma (NY-ESO-1^c259T cells). Confirmed antitumor responses occurred in 50% of patients (6/12) and were characterized by tumor shrinkage over several months. Circulating NY-ESO-1^c259T cells were present postinfusion in all patients and persisted for at least 6 months in all responders. Most of the infused NY-ESO-1^c259T cells exhibited an effector memory phenotype following ex vivo expansion, but the persisting pools comprised largely central memory and stem-cell memory subsets, which remained polyfunctional and s

SUBMITTER: D'Angelo SP 

PROVIDER: S-EPMC8092079 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature