DXA reference values of the humanoid sheep model in preclinical studies.

ABSTRACT:

Background

Merino land sheep are a popular pre-clinical large animal model in research on systemic skeletal diseases such as osteoporosis. Interpretation of studies is difficult because many reference parameters are missing or not established. This study aims to determine the reference parameters of the skeletal system (peak bone mass = PBM, T-Score). A defined standard allows an easier comparison of the study data of the animal model with human studies (T-Score).

Materials and methods

A total of 116 Dual Energy X-ray Absorptiometry DXA measurements were performed on 74 untreated sheep. The average age of the animals was 57 months. The BMD, BMC, and fat content of the sheep were determined by the relevant human region of interest (ROI). From this, the PBM and from this the T

SUBMITTER: Biehl C 

PROVIDER: S-EPMC8092102 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature