Mycophenolate suppresses inflammation by inhibiting prostaglandin synthases: a study of molecular and experimental drug repurposing.

ABSTRACT: Mycophenolate mofetil is an established anti-proliferative and immune-suppressive agent that minimizes the proliferation of inflammatory cells by interfering with nucleic acid synthesis. Herein, we report our discovery of the prostaglandin inhibiting properties of MMF, which offers new applications for the drug in the treatment of inflammatory diseases. The estimated values of IC₅₀MMF_COX-1, IC₅₀MMF_COX-2, and IC₅₀MMF_5-LOX were 5.53, 0.19, and 4.47 µM, respectively. In contrast, mycophenolic acid (MPA) showed slightly stronger inhibition: IC₅₀MPA_COX-1, IC₅₀MPA_COX-2, and IC₅₀MPA_5-LOX were 4.62, 0.14, and 4.49 µM, respectively. These results indicate that MMF and

SUBMITTER: Al-Hizab F 

PROVIDER: S-EPMC8092108 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature