EloR interacts with the lytic transglycosylase MltG at midcell in Streptococcus pneumoniae R6.

ABSTRACT: The ellipsoid shape of Streptococcus pneumoniae is determined by the synchronized actions of the elongasome and the divisome, which have the task of creating a protective layer of peptidoglycan (PG) enveloping the cell membrane. The elongasome is necessary for expanding PG in the longitudinal direction whereas the divisome synthesizes the PG that divides one cell into two. Although there is still little knowledge about how these two modes of PG synthesis are coordinated, it was recently discovered that two RNA-binding proteins called EloR and KhpA are part of a novel regulatory pathway controlling elongation in S. pneumoniae EloR and KhpA form a complex that work closely with the Ser/Thr kinase StkP to regulate cell elongation. Here, we have further explored how this regulati

SUBMITTER: Winther AR 

PROVIDER: S-EPMC8092159 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature