Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis.

ABSTRACT:

Purpose

Although the use of steroids in the management of COVID-19 has been addressed by a few systematic review and meta-analysis, however, they also used data from "SARS-CoV" and "MERS-CoV." Again, most of these studies addressed only one severity category of patients or addressed only one efficacy endpoint (mortality). In this context, we conducted this meta-analysis to evaluate the efficacy and safety of steroid therapy among all severity categories of patients with COVID-19 (mild to moderate and severe to critical category) in terms of "mortality," "requirement of mechanical ventilation," "requirement of ICU" and clinical cure parameters.

Methods

11 databases were screened. Only randomized controlled trials (RCTs) or high quality (on the basis of risk of bias analysis)

SUBMITTER: Sarma P 

PROVIDER: S-EPMC8092185 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature