Recurrent interactions in local cortical circuits.

ABSTRACT: Most cortical synapses are local and excitatory. Local recurrent circuits could implement amplification, allowing pattern completion and other computations^1-4. Cortical circuits contain subnetworks that consist of neurons with similar receptive fields and increased connectivity relative to the network average^5,6. Cortical neurons that encode different types of information are spatially intermingled and distributed over large brain volumes^5-7, and this complexity has hindered attempts to probe the function of these subnetworks by perturbing them individually⁸. Here we use computational modelling, optical recordings and manipulations to probe the function of recurrent coupling in layer 2/3 of the mouse vibrissal somatosensory cortex during active t

SUBMITTER: Peron S 

PROVIDER: S-EPMC8092186 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature