Intraspecies Transcriptional Profiling Reveals Key Regulators of Candida albicans Pathogenic Traits.

ABSTRACT: The human commensal and opportunistic fungal pathogen Candida albicans displays extensive genetic and phenotypic variation across clinical isolates. Here, we performed RNA sequencing on 21 well-characterized isolates to examine how genetic variation contributes to gene expression differences and to link these differences to phenotypic traits. C. albicans adapts primarily through clonal evolution, and yet hierarchical clustering of gene expression profiles in this set of isolates did not reproduce their phylogenetic relationship. Strikingly, strain-specific gene expression was prevalent in some strain backgrounds. Association of gene expression with phenotypic data by differential analysis, linear correlation, and assembly of gene networks connected both previously characteriz

SUBMITTER: Wang JM 

PROVIDER: S-EPMC8092256 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature