Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis.

ABSTRACT: In cystic fibrosis, dynamic and complex communities of microbial pathogens and commensals can colonize the lung. Cultured isolates from lung sputum reveal high inter- and intraindividual variability in pathogen strains, sequence variants, and phenotypes; disease progression likely depends on the precise combination of infecting lineages. Routine clinical protocols, however, provide a limited overview of the colonizer populations. Therefore, a more comprehensive and precise identification and characterization of infecting lineages could assist in making corresponding decisions on treatment. Here, we describe longitudinal tracking for four cystic fibrosis patients who exhibited extreme clinical phenotypes and, thus, were selected from a pilot cohort of 11 patients with repeated sampling for

SUBMITTER: Dmitrijeva M 

PROVIDER: S-EPMC8092271 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature