Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1.

ABSTRACT: The evolution of pathogens in response to selective pressures present during chronic infections can influence their persistence and virulence and the outcomes of antimicrobial therapy. Because subpopulations within an infection can be spatially separated and the host environment can fluctuate, an appreciation of the pathways under selection may be most easily revealed through the analysis of numerous isolates from single infections. Here, we continued our analysis of a set of clonally derived Clavispora (Candida) lusitaniae isolates from a single chronic lung infection with a striking enrichment in the number of alleles of MRR1 Genetic and genomic analyses found evidence for repeated acquisition of gain-of-function mutations that conferred constitutive Mrr1 acti

SUBMITTER: Demers EG 

PROVIDER: S-EPMC8092287 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature