Meta-analysis of animal studies applied to short-term inhalation exposure levels of hazardous chemicals.

ABSTRACT: For short-term chemical inhalation exposures to hazardous chemicals, the incidence of a health effect in biological testing usually conforms to a general linear model with a probit link function dependent on inhalant concentration C and the duration of exposure t. The National Academy's Acute Exposure Guideline Levels (AEGLs) Committee relies on these models when establishing AEGLs. Threshold concentrations at AEGL durations are established by the toxic load equation Cⁿ x t = constant, which toxic load exponent n (TLE or n-value) directly follows from the bivariate probit model. When multiple probit datasets are available, the AEGL Committee routinely pools studies' incidence data. Such meta-analytical models are valid only when the pooled data are homogeneous, with similar sens

SUBMITTER: Prussia AJ 

PROVIDER: S-EPMC8092449 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature