Dihydrotanshinone I Is Effective against Drug-Resistant Helicobacter pylori In Vitro and In Vivo.

ABSTRACT: Helicobacter pylori is a major global pathogen and has been implicated in gastritis, peptic ulcer, and gastric carcinoma. The efficacy of the extensive therapy of H. pylori infection with antibiotics is compromised by the development of drug resistance and toxicity toward human gut microbiota, which urgently demands novel and selective antibacterial strategies. The present study was mainly performed to assess the in vitro and in vivo effects of a natural herbal compound, dihydrotanshinone I (DHT), against standard and clinical H. pylori strains. DHT demonstrated effective antibacterial activity against H. pyloriin vitro (MIC_50/90, 0.25/0.5 μg/ml), with no development of resistance during continuous serial passaging. Time-kill curv

SUBMITTER: Luo P 

PROVIDER: S-EPMC8092497 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature