Piperaquine Pharmacokinetics during Intermittent Preventive Treatment for Malaria in Pregnancy.

ABSTRACT: Dihydroartemisinin-piperaquine (DP) is a long-acting artemisinin combination treatment that provides effective chemoprevention and has been proposed as an alternative antimalarial drug for intermittent preventive therapy in pregnancy (IPTp). Several pharmacokinetic studies have shown that dose adjustment may not be needed for the treatment of malaria in pregnancy with DP. However, there are limited data on the optimal dosing for IPTp. This study aimed to evaluate the population pharmacokinetics of piperaquine given as IPTp in pregnant women. Pregnant women were enrolled in clinical trials conducted in Kenya and Indonesia and treated with standard 3-day courses of DP, administered in 4- to 8-week intervals from the second trimester until delivery. Pharmacokinetic blood samples were collecte

SUBMITTER: Chotsiri P 

PROVIDER: S-EPMC8092554 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature