Neural substrates of neuropsychological profiles in dystrophynopathies: A pilot study of diffusion tractography imaging.

ABSTRACT:

Introduction

Cognitive difficulties and neuropsychological alterations in Duchenne and Becker muscular dystrophy (DMD, BMD) boys are not yet sufficiently explored, although this topic could have a relevant impact, finding novel biomarkers of disease both at genetics and neuroimaging point of view. The current study aims to: 1) analyze the neuropsychological profile of a group of DMD and BMD boys without cognitive impairment with an assessment of their executive functions; 2) explore the structural connectivity in DMD, BMD, and age-matched controls focusing on cortico-subcortical tracts that connect frontal cortex, basal ganglia, and cerebellum via the thalamus; 3) explore possible correlations between altered structural connectivity and clinical neuropsychological measures.

Mate

SUBMITTER: Biagi L 

PROVIDER: S-EPMC8092766 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature